Sayyiduna Rasulullah (sallal laahu alaihi wasallam) had children from only two of his wives. They were Sayyadah Khadijah (radi Allahu anha) and Sayyadah Maria Qibtiya (radi Allahu anha).
 
 
 

Sayyadah Khadijah (radi Allahu anha) had 6 children. They were:

A.Sayyiduna Qasim (radi Allahu anhu): He was the eldest son and passed away in infancy.

B.Sayyiduna Abdullah (radi Allahu anhu): He was born during the period of Prophethood and was called "Tayyab" and "Taahir." He also passed away in infancy.

C.Sayyadah Zaynab (radi Allahu anha): She was the eldest daughter. She married Sayyiduna Abul Aas (radi Allahu anhu) who only accepted Islam just a year after she passed away in 8 A.H. She passed away from a wound she received while on the Hijrah to Madinatul Munawwarah. She had two children - Sayyiduna Ali (radi Allahu anhu) and Sayyiduna Umama (radi Allahu anhu).

D.Sayyadah Ruqayyah (radi Allahu anha): She was first married to Utba, son of Abu Lahab. She did not live with him and he divorced her. She then married Sayyiduna 'Uthman (radi Allahu anhu) and migrated with him to Abyssinia and finally settled in Madinatul Munawwarah. They had one son, Sayyiduna Abdullah (radi Allahu anhu) who passed away at the age of 6. She passed away in 2 A.H. after an illness.

E.Sayyadah Umme Kulthum (radi Allahu anha): She was first married to Utaibah, another son of Abu Lahab. She did not want to live with him and he divorced her. In 3 A.H. she married Sayyiduna 'Uthman (radi Allahu anhu). His first wife, Sayyadah Ruqayyah (radi Allahu anha), passed away. She passed away in Shabaan of 9 A.H.

F.Sayyadah Fathima (radi Allahu anhu): She was the youngest daughter of Sayyiduna Rasulullah (sallal laahu alaihi wasallam). She married Sayyiduna Ali (radi Allahu anhu). They had 3 sons and 2 daughters. Sayyiduna Imam Hassan, Sayyiduna Imam Hussain, Sayyiduna Mohsin, Sayyadah Umme Kulthum and Sayyadah Zainab (radi Allahu anhumul ajma'in). She passed away a few months after Sayyiduna Rasulullah (sallal laahu alaihi wasallam) left this world. She is considered to be "Sayyidatun Nisaa min Ahlil Jannah" or "Leader of the Women of Paradise."

She born  a son, Sayyiduna Ibrahim (radi Allahu anhu), who passed away in infancy.